AI Article Synopsis
- The semipinacol rearrangements (SPRs) are effective methods for creating complex carbon structures, including quaternary stereocenters, essential in natural products and drugs.
- Recent research has focused on metal carbene-induced SPRs, which offer a promising route to synthesize important carbonyl compounds.
- This review discusses recent developments in metal carbene-induced SPRs, covering mechanisms, applications, limitations, and future challenges and opportunities in the field.
Article Abstract
As has been well-recognized, the semipinacol rearrangements (SPRs) function as a powerful and versatile tool for the construction of all-carbon and heteroatom-containing quaternary stereocenters, which are present in various natural products and bioactive molecules. In recent years, considerable attention has been paid to exploring the metal carbene-induced semipinacol rearrangements, providing an attractive and powerful strategy for obtaining various important carbonyl compounds. However, to date, no review has been published that summarizes the significant advances in the preparation of functionalized carbonyl compounds using these migration rearrangement reactions. In this review article, we have summarised the recent advances in the field of metal carbene-induced SPR reactions according to different metal classifications. Mechanistic insights, synthetic applications, and their limitations are discussed. The challenges and opportunities in this field are also outlined.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc03252g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!