AI Article Synopsis
- High altitude polycythemia happens when people living in high places have too many red blood cells because there's less oxygen.
- This can make it hard for their hearts and lungs to work properly, leading to serious health problems.
- The review studied how different factors, like sleep issues and hormones, cause these problems and make the condition worse.
Article Abstract
High altitude polycythemia is a maladaptation of highlanders exposed to hypoxic environment, leading to high blood viscosity and severe cardiorespiratory dysfunction. Prolonged hypoxia causes respiratory depression and severe hypoxemia, and further mediates changes in genetic and molecular mechanisms that regulate erythropoiesis and apoptosis, ultimately resulting in excessive erythrocytosis (EE). This updated review investigated the maladaptive mechanisms of EE, including respiratory chemoreceptor passivation, sleep-related breathing disorders, sex hormones, iron metabolism, and hypoxia-related factors and pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383785 | PMC |
| http://dx.doi.org/10.3389/fmed.2024.1448654 | DOI Listing |
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