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Peptide Alkyl Thioester Synthesis from Advanced Thiols and Peptide Hydrazides. | LitMetric

Peptide Alkyl Thioester Synthesis from Advanced Thiols and Peptide Hydrazides.

J Org Chem

Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille F-59000, France.

Published: September 2024

AI Article Synopsis

Article Abstract

Peptide alkyl thioesters are versatile reagents in various synthetic applications, commonly generated from peptide hydrazides and thiols. However, a notable limitation is the need for a substantial excess of the thiol reagent, restricting the usage to simple thiols. Here, we introduce an adapted procedure that significantly enhances thioester production with just a minimal thiol excess, facilitating the use of advanced thiol nucleophiles.

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http://dx.doi.org/10.1021/acs.joc.4c01251DOI Listing

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