AI Article Synopsis

  • This study evaluates how demographic factors and comorbid conditions impact the prognosis and treatment of patients with laryngeal squamous cell cancer (LSCC) based on medical records from 2008 to 2019.
  • A total of 573 patients were analyzed, revealing that the majority were men and smokers, with significant survival rates indicating better outcomes for early-stage LSCC treated with endolaryngeal laser surgery (ELS) compared to radiotherapy.
  • It was concluded that ELS offers superior overall and disease-free survival rates for early-stage LSCC, while advanced cases showed better outcomes with total laryngectomy compared to chemoradiotherapy; recurrence risk was notably higher in certain categories of tumors.*

Article Abstract

Objective: In this study, we aimed to evaluate the effects of demographic data and comorbid diseases on the prognosis and treatment diagnosed with laryngeal squamous cell cancer (LSCC).

Methods: Medical records of LSCC patients treated and followed up in a single referral center between 2008 and 2019 were retrospectively reviewed. In addition to the demographic data, the results of overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional-free survival (LRFS), and factors affecting recurrence were analyzed.

Results: We included 573 patients with a mean age of 60.1±9.8 years. Of the 573 patients, 94.2% (540) were men, 93.7% (537) were smokers, 40.1% had at least one comorbid disease, and 69.8% (400) presented with glottic LSCC. The five-year OS, DSS, DFS, and LRFS rates for all cases were 65.7%, 79.9%, 67%, and 74.7%, respectively. In early-stage LSCC treatment, the rates of OS (p=0.008), DFS (p=0.024) and LRFS (p=0.01) were statistically significantly higher in the endolaryngeal laser surgery (ELS) group compared with the radiotherapy (RT) group. In advanced-stage LSCC treatment, total laryngectomy had statistically significantly higher five-year DFS (p=0.003) and LRFS (p=0.002) rates compared to chemoradiotherapy.

Conclusion: Our study showed that ELS provided higher rates of OS, DFS, and LRFS compared to RT in the treatment of early-stage LSCC. Recurrence was significantly higher in supraglottic tumors, advanced-stage tumors, and in patients with clinical N positivity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587523PMC
http://dx.doi.org/10.4274/tao.2024.2023-12-2DOI Listing

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