AI Article Synopsis

  • * Safflower yellow, a natural pigment, is evaluated for its effectiveness and safety as an added therapy alongside traditional diabetes treatments through a meta-analysis of 28 studies covering 2,251 patients.
  • * The findings reveal that patients using safflower yellow experienced improvements in key health markers and showed greater clinical benefit, proving it to be a more cost-effective option compared to conventional treatments alone.

Article Abstract

Diabetic nephropathy (DN) is one of the most important comorbidities of diabetic patients, which places large physiological and economic burdens on patients. Safflower yellow, a natural pigment extracted from the petals of safflower, has been put into adjuvant therapy. Databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, MEDLINE and etc. will be searched for relevant articles. A meta-analysis was carried out to assess the efficacy and safety of safflower yellow adjuvant to conventional treatment regimen using mean differences (MD) and rate ratios (RR). A cost-effectiveness analysis was also conducted based on the result of meta-analysis. Finally, 28 articles involving 2251 patients were included in meta-analysis. The results showed that compared with conventional treatment, the fasting blood-glucose (FBG) [MD = 0.40], urinary albumin ejection rate (UAER) within 24 h [MD = 48.16], serum creatinine (Scr) [MD = 9.63], blood urea nitrogen (BUN) [MD = 1.73] were significantly lower and the clinical efficacy [RR = 1.28] was more remarkable in safflower yellow adjuvant to conventional treatment group. Our analysis suggested that safflower yellow adjuvant to conventional treatment regimen not only had better clinical efficacy but more cost-effective than conventional treatment regimen.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387831PMC
http://dx.doi.org/10.1038/s41598-024-64216-zDOI Listing

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