AI Article Synopsis
- Short-chain fatty acids (SCFAs), like acetate, propionate, and butyrate, are produced by bacteria in the colon and help protect against gastrointestinal diseases.
- These metabolites are essential for maintaining a healthy gut barrier and have been linked to benefits in colorectal cancer (CRC).
- The article will explore how SCFAs are metabolized, their mechanisms of action, and the impact of dietary fiber on CRC, along with updates from clinical research.
Article Abstract
Short-chain fatty acids (SCFAs) are produced by bacterial fermentation in the colon and are thought to be protective against gastrointestinal disease. SCFAs such as acetate, propionate and butyrate are important metabolites in the maintenance of intestinal homeostasis and have been shown to be beneficial in colorectal cancer (CRC). SCFAs are responsible for maintaining a normal intestinal barrier and exhibit numerous immunomodulatory functions. In this review article, we will discuss the metabolism and mechanism of action of SCFAs and their effects on the CRC, with particular emphasis on dietary fiber treatment and the clinical research progress.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387572 | PMC |
| http://dx.doi.org/10.1007/s12672-024-01313-5 | DOI Listing |
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