Ferroptosis, a novel cell death mode driven by iron-dependent phospholipid (PL) peroxidation, has emerged as a promising therapeutic strategy for the treatments of cancer, cardiovascular diseases, and ischemic-reperfusion injury (IRI). PL peroxidation, the key process of ferroptosis, requires polyunsaturated fatty acid (PUFA)-containing PLs (PL-PUFAs) as substrates, undergoing a chain reaction with iron and oxygen. Cells prevent ferroptosis by maintaining a homeostatic equilibrium among substrates, processes, and detoxification of PL peroxidation. Sterols, lipids abundant in cell membranes, directly participate in PL peroxidation and influence ferroptosis sensitivity. Sterol metabolism also plays a key role in ferroptosis, and targeting sterols presents significant potential for treating numerous ferroptosis-associated disorders. This review elucidates the fundamental mechanisms of ferroptosis, emphasizing how sterols modulate this process and their therapeutic potential.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.molmed.2024.08.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.
Tissue Cell
December 2024
Department of Pathology, The Fourth Hospital of Changsha, Changsha, Hunan 410006, PR China. Electronic address:
Background: Telomere maintenance is an important feature of tumor cells. Telomeric-repeat binding factor 1 interaction nuclear protein 2 (TIN2), a key member of the shelterin proteins, functions in regulating telomere structure, length and function. Our work sought to investigate the role of TIN2 in controlling gastric cancer (GC) malignant biological behaviors.
View Article and Find Full Text PDFHedyotis diffusa injection modulates the ferroptosis in bladder cancer via CAV1/JUN/VEGFA.
Int Immunopharmacol
January 2025
Department of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai 200127, China. Electronic address:
Hedyotis diffusa Willd. (HDW), a traditional Chinese medicinal plant, exhibits a variety of pharmacological effects and has anticancer potential for a wide range of cancer types; Ferroptosis is a non-apoptosis-regulated cell death induced by iron accumulation and subsequent lipid peroxidation; and there is currently an increasing interest in the therapeutic role of ferroptosis in cancer. However, the effects of HDW on bladder cancer and its underlying molecular mechanisms remain largely unknown.
View Article and Find Full Text PDFDevelopment of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis.
Mol Immunol
January 2025
Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address:
Sepsis, a common and life-threatening condition often leading to multiple organ dysfunction, currently lacks a prognostic model based on ferroptosis-related genes (FRGs) for predicting clinical outcomes. In this study, we utilized the FerrDb database and GSE65682 dataset to evaluate the prognostic significance of FRGs in sepsis. Differential expression analysis identified 27 DE-FRGs, and Consensus clustering revealed three distinct FRG molecular subtypes in sepsis with notable differences in immune infiltration landscapes.
View Article and Find Full Text PDFBergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Phytother Res
January 2025
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation.
View Article and Find Full Text PDFBeta-propeller Protein Associated Neurodegeneration (BPAN) is a devastating neurodevelopmental and neurodegenerative disease linked to variants in . Currently, there is no cure or disease altering treatment for this disease. This is, in part, due to a lack of insight into early phenotypes of BPAN progression and 's role in establishing and maintaining neurological function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!