Neuregulin-1 immunoreactivity in peripheral plasma is associated with rs6982890 polymorphism-mediated psychotic symptoms in schizophrenia.

Brain Res Bull

The Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Xinxiang, China; Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, China; Henan Collaborative Innovation Center of Prevention and treatment of mental disorder, Xinxiang, China. Electronic address:

Published: October 2024

AI Article Synopsis

  • - The study focuses on Neuregulin 1 (NRG1), a gene linked to schizophrenia, examining how the rs6982890 SNP affects psychotic symptoms and cognitive functions in patients.
  • - Researchers analyzed data from over 1,300 schizophrenia patients and 871 healthy controls in Northern China, measuring NRG1 levels and correlating them with clinical symptoms before and after 8 weeks of treatment.
  • - Results showed that rs6982890 is associated with schizophrenia, revealing that patients with the CC genotype had significantly improved NRG1 levels and symptoms after treatment, while those with the CT genotype did not show significant changes.

Article Abstract

Objectives: Neuregulin 1 (NRG1) is a risk gene for schizophrenia and involved in neurodevelopment and synaptic plasticity. Polymorphisms in NRG1 may affect psychotic symptoms in schizophrenia. This study investigated the effects of the single nucleotide polymorphism (SNP) rs6982890 on peripheral plasma NRG1 immunoreactivity, clinical symptoms and cognitive functions in schizophrenia patients.

Material And Methods: We recruited subjects from the Han population of northern China from 2010 to 2022. We first genotyped and analyzed 6 NRG1 SNPS in 1304 patients with schizophrenia and 871 healthy controls. Then, 91 patients with schizophrenia and 40 healthy controls were selected to detect the peripheral plasma NRG1 immunoreactivity by ELISA. Among them, 84 patients were divided into rs6982890 genotypes to analyze the correlation between NRG1 immunoreactivity and clinical symptoms.

Results: Rs6982890 allelic frequencies were statistically significant between patients and controls. Baseline peripheral plasma NRG1 immunoreactivity in patients were significantly lower than controls. NRG1 immunoreactivity in patients were significantly increased after 8 weeks of antipsychotic treatment and significantly correlated with clinical symptoms and cognitive function. Genotyping of patients with SNP rs6982890 indicated NRG1 immunoreactivity in CC genotype increased significantly after treatment, while CT genotype had no significant change. Baseline NRG1 immunoreactivity with the CT genotype were significantly higher than CC genotype.

Conclusions: NRG1 SNP rs6982890 is significantly associated with schizophrenia in the Han population of northern China, and it may affect the effect of antipsychotic drug treatment by regulating the peripheral plasma NRG1 immunoreactivity.

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Source
http://dx.doi.org/10.1016/j.brainresbull.2024.111075DOI Listing

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