AI Article Synopsis

  • Solar lentigo is a common skin condition that can be effectively treated using a combination of traditional Chinese medicines and their active compounds.
  • The study employed advanced techniques like liquid chromatography-mass spectrometry and network pharmacology to identify key compounds and assess their effects on pigmentation in both mice and humans.
  • Results showed that the treatment significantly reduced UVB-induced pigmentation and improved skin health, confirming the potential of TCMM as a comprehensive treatment strategy.

Article Abstract

Background And Aims: Solar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In this study, we evaluated the efficacy and underlying mechanism of TCMM, a combination of TCM and monomers in repairing solar lentigo.

Methods: We detected and identified the main compounds of TCM using liquid chromatography-mass spectrometry (LC-MS) and through the approach of network pharmacology, we screened drug and disease targets, visualized networks with Cytoscape software, analyzed targets via Gene ontology and KEGG, clinically validated predictions. In a mouse model, UVB-induced pigmentation was assessed, and the effects of TCMM were evaluated. A clinical trial on 30 patients validated the depigmenting agent.

Results: Active ingredients such as MSH, Butylated hydroxytoluen, Valerophenone, and Geranylacetone aid pigmentation treatment. One hundred and forty-three crore targets impact PI3K-Akt, MAPK signaling pathway, ect. pathways. TCMM reduced UVB-induced pigmentation, water loss, epidermal thickness, and melanin. It inhibited TYR, MITF, AKT1, VEGFA, PTGS2, TNF-α, IL-6, IL-1β. Clinical and microscopic analysis showed significant pigmentation reduction.

Conclusions: The treatment of solar lentigo can benefit from the TCMM. By targeting multiple factors and pathways, this approach offers a comprehensive and effective treatment strategy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626378PMC
http://dx.doi.org/10.1111/jocd.16507DOI Listing

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