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| http://dx.doi.org/10.1016/j.omtn.2024.102293 | DOI Listing |
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Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.
Nat Commun
January 2025
Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, PR China.
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable oligomers (IOs) that, with polylactide-polyethylene glycol (PLA-PEG), form a potential siRNA delivery system, named Ionizable Polymeric Micelles (IPMs). The siRNA encapsulated IPMs escape from lysosomes upon cellular uptake, and silence the target gene.
View Article and Find Full Text PDFPLA-PEG as an alternative to PEGylated lipids for nanoparticle-based DNA vaccination against SARS-CoV-2.
Mol Ther Nucleic Acids
September 2024
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.
Pharmaceutics
July 2024
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.
In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog of the "pegylated" PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEM analyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cyto- and hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate () were also studied.
View Article and Find Full Text PDFDonepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles.
Int J Nanomedicine
February 2024
Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Québec, Canada.
Article Synopsis
- Drug delivery to the brain is crucial for treating neurodegenerative diseases like Alzheimer's, and traditional methods face obstacles due to the blood-brain barrier (BBB).
- The study developed two novel drug delivery systems—extracellular vesicles (EVs) and polymer nanoparticles (NPs-PLA-PEG)—to enhance the transport and effectiveness of Donepezil (DNZ), an Alzheimer's medication, across the BBB.
- Results indicated that EVs better targeted the brain and did not cause hyperactivity in zebrafish, displaying potential as a more efficient delivery method compared to nanoparticles for neurodegenerative treatments.
Ectoenzymes as promising cell identification structures for the high avidity targeting of polymeric nanoparticles.
Int J Pharm
November 2023
Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Bavaria 93053, Germany. Electronic address:
Article Synopsis
- Pharmacotherapy can have side effects and not enough medicine gets to where it’s needed, which is a problem for patients.
- Active-targeted nanotherapy uses tiny particles with special tags (ligands) that find and attach to specific cells, helping the medicine work better.
- Researchers tested a new method using an enzyme inhibitor in these nanoparticles and found it was really good at finding the right cells without causing unwanted side effects.
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