AI Article Synopsis
- As we get older, the system that makes our blood cells (the hematopoietic system) starts to change and doesn't work as well.
- This causes problems like making more of certain blood cells and fewer B and T cells, which help our immune system.
- Also, there are changes in the details of how our cells work at a microscopic level that make these aging effects happen more and can lead to more inflammation in the body.
Article Abstract
Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage-biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone marrow. Both alterations in RNA splicing and editing during HSC aging contribute to increased myeloid lineage skewing and inflammation-responsive transcription factors, underscoring the importance of epitranscriptomic mechanisms in the acquisition of an age-related phenotype.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586592 | PMC |
| http://dx.doi.org/10.1002/1873-3468.15014 | DOI Listing |
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