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It's about time: moving away from statistical analysis of ecotoxicity data.
Integr Environ Assess Manag
January 2025
DEBtox Research, Stevensweert, The Netherlands.
Environmental risk assessment of chemicals (ERA) relies on single-species laboratory testing to establish the toxic properties of a compound. However, ERA is not concerned with toxicity under laboratory conditions: it needs to assess the impacts of the compound in the real world. Data-driven statistical analyses (e.
View Article and Find Full Text PDFThe conserved global regulator H-NS has a strain-specific impact on biofilm formation in symbionts.
bioRxiv
December 2024
Earth, Marine & Environmental Sciences Department, University of North Carolina, Chapel Hill, NC.
Unlabelled: Strain-level variation among host-associated bacteria often determines host range and the extent to which colonization is beneficial, benign, or pathogenic. is a beneficial symbiont of the light organs of fish and squid with known strain-specific differences that impact host specificity, colonization efficiency, and interbacterial competition. Here, we describe how the conserved global regulator, H-NS, has a strain-specific impact on a critical colonization behavior: biofilm formation.
View Article and Find Full Text PDFImpact of delayed adoption of novel atrial fibrillation treatments.
Am J Manag Care
December 2024
Center for Healthcare Economics and Policy, FTI Consulting, 350 S Grande Ave, Los Angeles, CA 90071. Email:
Objective: To examine the relationship between adoption of direct oral anticoagulants (DOACs) and health and cost outcomes for patients with nonvalvular atrial fibrillation.
Study Design: Real-world cohort study.
Methods: US adults who newly initiated treatment for nonvalvular atrial fibrillation were identified from claims data.
Deep generative abnormal lesion emphasization validated by nine radiologists and 1000 chest X-rays with lung nodules.
PLoS One
December 2024
Department of Radiology and Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
A general-purpose method of emphasizing abnormal lesions in chest radiographs, named EGGPALE (Extrapolative, Generative and General-Purpose Abnormal Lesion Emphasizer), is presented. The proposed EGGPALE method is composed of a flow-based generative model and L-infinity-distance-based extrapolation in a latent space. The flow-based model is trained using only normal chest radiographs, and an invertible mapping function from the image space to the latent space is determined.
View Article and Find Full Text PDFMediolateral Margin of Stability highlights motor strategies for maintaining dynamic balance in older adults.
PLoS One
October 2024
Center for Digital Health & Social Innovation, St. Poelten University of Applied Sciences, St. Pölten, Austria.
The dynamical nature of gait increases fall risk for older adults as the Center of Mass (COM) is constantly displaced inside and outside the Base of Support (BOS). Foot placement and leg joint moments are the primary mechanisms controlling dynamic balance. The Margin of Stability (MOS) quantifies the distance between the COM dynamical state and the BOS.
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