Ganglioneuroblastoma a transitional tumor of sympathetic origin has not yet been described as involving orbit. It is characterized by a mixture of cells ranging from primitive neuroblast to well differentiated ganglion cells within a neurofibromatous tissue. The prognosis is uncertain, as the tumor may either undergo maturation into a ganglioneuroma or may metastasize widely and rapidly as in neuroblastoma. We may postulate a relationship between ganglioneuroblastoma and Recklinghausen's neurofibromatosis in view of the development of the tumor in conjunction with the phacomatosis.
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Primary orbital ganglioneuroblastoma: A case report.
Open Med (Wars)
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Department of Ophthalmology, Ophthalmic Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Background: Ganglioneuroblastoma (GNB) is a neoplasm that arises from the primitive cells of the sympathetic nervous system during childhood. The current case is very unique because of the initial primary tumor manifestation in the orbit and an adrenal tumor being observed later during follow-up.
Case Presentation: A 2-year-old girl presented to the Ophthalmology Department of our hospital complaining of swelling of the left upper eyelid for approximately one month.
Coexistence of orbital rhabdomyosarcoma and adrenal neuroblastic tumor in a child.
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Department of Pediatric Oncological Surgery, National Center for Children's Health (Beijing), Beijing Children's Hospital, Capital Medical University, Beijing, China.
Primary orbital ganglioneuroblastoma in a child: A case report.
Medicine (Baltimore)
November 2020
Department of Ophthalmology, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan Province, China.
Rationale: Ganglioneuroblastoma (GNB) is a transitional tumor of sympathetic origin that has never been described as primarily involving the orbit. Herein we report an extremely rare case of GNB with primary orbital involvement and its treatment strategies.
Patient Concerns: A 9-year-old girl presented with progressive and recurring right orbital mass for 2 years.
The late recurrence of ganglioneuroma 21 years after initial presentation with neuroblastoma.
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Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
A 3-year-old boy presented with tumors in the adrenal gland and the right orbit, and was diagnosed with neuroblastoma. After chemotherapy, the tumors were resected and the pathological diagnoses of ganglioneuroblastoma in the adrenal gland and ganglioneuroma in the orbit were made. The tumor relapsed at the intracranial dura mater 21 years after the initial diagnosis, and was diagnosed as ganglioneuroma from a biopsied sample.
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