AI Article Synopsis
- The study reviewed the effectiveness and safety of Rituximab (RTX) in treating IgA vasculitis nephritis (IgAVN), involving 41 patients analyzed up to December 29, 2023.* -
- Results showed stabilization of renal function and normalization of urinalysis post-RTX treatment, with 40% of patients able to stop using glucocorticoids and high remission rates (92.7% overall and 46.3% complete remission).* -
- Remarkably, child patients treated with RTX had a higher complete remission rate (76.9%) compared to adults (32.1%), indicating RTX may be particularly beneficial for younger patients.*
Article Abstract
The utility of Rituximab (RTX) for IgA vasculitis nephritis (IgAVN) is not well established. Up to now, we analysed the largest samples of IgAVN patients treated by RTX with a total of 41 retrieved subjects up to December 29, 2023 in the present systematic review. We assessed the clinical profiles, efficacy, and safety of RTX treatments. The present review showed that the renal function tended to be stabilized (P = 1.000) and urinalysis tended to normalize after RTX treatment with no serious adverse events reported. Moreover, 40% (16/40) of patients was freed use of glucocorticoid after RTX administration (P < 0.001). The remission rate was 92.7% (38/41) and complete remission rate was 46.3% (19/41) in IgAVN patients. Interestingly, 76.9% (10/13) of IgAVN child patients achieved complete remission when compared with 32.1% (9/28) of adult patients (P = 0.017). In summary, our results support the benefit of RTX therapy in IgAVN patients, especially children subjects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383840 | PMC |
| http://dx.doi.org/10.1007/s10238-024-01461-6 | DOI Listing |
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