Waste management has gained global importance, aligning with the escalating impact of the COVID-19 pandemic and the associated concerns regarding medical waste, which poses threats to public health and environmental sustainability. In Istanbul, medical waste is considered a significant concern due to the rising volume of this waste, along with challenges in collection, incineration and storage. At this juncture, precise estimation of the waste volume is crucial for resource planning and allocation. This study, thus, aims to estimate the volume of medical waste in Istanbul using the nonlinear grey Bernoulli model (NGBM(1,1)) and the firefly algorithm (FA). In other words, this study introduces a novel hybrid model, termed as FA-NGBM(1,1), for predicting waste amount in Istanbul. Within this model, prediction accuracy is enhanced through a rolling mechanism and parameter optimization. The effectiveness of this model is compared with the classical GM(1,1) model, the GM(1,1) model optimized with the FA (FA-GM(1,1)), the fractional grey model optimized with the FA (FA-FGM(1,1)) and linear regression. Numerical results indicate that the proposed FA-NGBM(1,1) hybrid model yields lower prediction error with a mean absolute percentage error value 3.47% and 2.57%, respectively, for both testing and validation data compared to other prediction algorithms. The uniqueness of this study is rooted in the process of initially optimizing the parameters for the NGBM(1,1) algorithm using the FA for medical waste estimation in Istanbul. This study also forecasts the amount of medical waste in Istanbul for the next 3 years, indicating a dramatic increase. This suggests that new policies should be promptly considered by decision-makers and practitioners.
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http://dx.doi.org/10.1177/0734242X241271065 | DOI Listing |
Antimicrob Steward Healthc Epidemiol
September 2024
Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
Background: Amoxicillin suspension is frequently prescribed to children; we hypothesized that prescribing convention system constraints lead to unusual dosing regimens and unnecessary waste of the drug.
Objective: Identify antibiotic dispensing practices by community pharmacists and/or technicians to understand opportunities to decrease wasted amoxicillin liquid and optimize prescribing convention of liquid amoxicillin to children.
Methods: Pilot online survey of Atlanta area and National Community Pharmacists Association pharmacists or pharmacy technicians that self-reported dispensing amoxicillin suspension.
Neural Regen Res
January 2025
Molecular Neuropharmacology Laboratory and Eye-Brain Research Center, State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of disease-modifying treatments. The glymphatic system, a recently identified perivascular fluid transport network, is crucial for clearing neurotoxic proteins. This review aims to synthesize current knowledge on the role of the glymphatic system in α-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
January 2025
Medical Center for Information and Communication Technology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Background: Molecular tumor boards (MTBs) play a pivotal role in personalized oncology, leveraging complex data sets to tailor therapy for cancer patients. The integration of digital support and visualization tools is essential in this rapidly evolving field facing fast-growing data and changing clinical processes. This study addresses the gap in understanding the evolution of software and visualization needs within MTBs and evaluates the current state of digital support.
View Article and Find Full Text PDFJ Neurol Sci
January 2025
Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:
Background: The glymphatic system, essential for brain waste clearance, has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Emerging imaging markers, such as the analysis along the perivascular space (ALPS) index and choroid plexus volume (CPV), may provide insights into glymphatic function, but their relevance to ALS remains unclear.
Objective: To assess glymphatic dysfunction in ALS patients using the ALPS index and CPV.
Well-designed effective interventions promoting sustainable diets are urgently needed to benefit both human and planetary health. This study evaluated the feasibility, acceptability, and potential impact of a pilot blended digital intervention aimed at promoting sustainable diets. We conducted a series of ABA n-of-1 trials with baseline, intervention, and follow-up phases over the course of a year, involving twelve participants.
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