A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Copper-Catalyzed Nucleophilic Cycloisomerization Cascade Constructing Azepinoindolizine. | LitMetric

Copper-Catalyzed Nucleophilic Cycloisomerization Cascade Constructing Azepinoindolizine.

Org Lett

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, People's Republic of China.

Published: September 2024

Numerous effective bioisosteric replacements have been identified through substituting scaffolds and functional groups in lead molecules with alternative ones that preserve or enhance the desired biological activity of the original compound. Here, a copper-catalyzed nucleophilic cycloisomerization was developed to access potential bioisosteric replacements of azepinoindole. In this process, "tetra-alkene" characteristic of indolizine undergoes a 12π electrocyclization, offering a complementary method to obtain azepinoindolizine derivatives that are otherwise challenging to prepare through conventional means.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.4c02933DOI Listing

Publication Analysis

Top Keywords

copper-catalyzed nucleophilic
8
nucleophilic cycloisomerization
8
bioisosteric replacements
8
cycloisomerization cascade
4
cascade constructing
4
constructing azepinoindolizine
4
azepinoindolizine numerous
4
numerous effective
4
effective bioisosteric
4
replacements identified
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!