AI Article Synopsis
- Hereditary angioedema (HAE) is a rare condition characterized by a deficiency in C1 esterase inhibitor, leading to recurrent episodes of swelling, which can worsen during pregnancy due to hormonal changes and stress.
- A case study describes a pregnant patient with HAE who successfully had a vaginal delivery with neuraxial anesthesia, highlighting the importance of C1-inhibitor prophylaxis and postpartum monitoring.
- Effective management of HAE during pregnancy and delivery requires timely consultations, access to emergency airway supplies, and a coordinated approach among healthcare providers to ensure the safety of both the mother and baby.
Article Abstract
Hereditary angioedema (HAE) is a rare disorder due to C1 esterase inhibitor deficiency, causing recurrent swelling. Pregnancy can exacerbate HAE due to estrogen fluctuations alongside peripartum stress and trauma. We present a pregnant patient with HAE who underwent induction of labor and vaginal delivery with neuraxial anesthesia. Management included C1-inhibitor prophylaxis, 48 hours of postpartum monitoring, and a self-treatment plan at discharge. Angioedema prevention involves timely anesthesia consultation, accessible emergency airway equipment, early neuraxial anesthesia, planned vaginal delivery, and 48 to 72 hours of close postpartum monitoring. Readily available C1-inhibitor and a multidisciplinary approach with these recommendations are crucial for peripartum management.
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| http://dx.doi.org/10.1213/XAA.0000000000001833 | DOI Listing |
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