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Microbially derived surfactants: an ecofriendly, innovative, and effective approach for managing environmental contaminants.
Front Bioeng Biotechnol
August 2024
Amity Institute of Biotechnology, Amity University, Noida, India.
Article Synopsis
- - Hydrophobic pollutants like long-chain hydrocarbons and heavy metals are harmful to the environment and human health, and traditional chemical surfactants used for decontamination can be toxic.
- - Biosurfactants, produced by various microbes, are a safer and more cost-effective alternative to chemical surfactants, capable of breaking down pollutants and enhancing their solubility by reducing surface tension.
- - The effectiveness of biosurfactants in remediation depends on several factors such as temperature, pH, and media composition, and recent discussions include their potential in a circular bioeconomy by utilizing waste for biosurfactant production.
Editorial: Emulsifiers and thickeners in our food-Do they alter gut permeability?
Aliment Pharmacol Ther
October 2024
Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.
Editorial: Emulsifiers and thickeners in our food-Do they alter gut permeability? Authors' reply.
Aliment Pharmacol Ther
October 2024
Department of Gastroenterology, School of Translational Medicine, Monash University and Alfred Health, Melbourne, Victoria, Australia.
Lymphatic Uptake of a Highly Lipophilic Protease Inhibitor Prodrug from a Lipid-Based Formulation is Limited by Instability in the Intestine.
J Pharm Sci
August 2024
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. Electronic address:
Dabigatran etexilate (DABE) is a lipophilic double alkyl ester prodrug of dabigatran (DAB) which is a serine protease inhibitor used clinically as an anticoagulant. Recently, translocation of serine protease enzymes, including trypsin, from the gut into the mesenteric lymph and then blood has been associated with organ failure in acute and critical illnesses (ACIs). Delivery of DABE into mesenteric lymph may thus be an effective strategy to prevent organ failure in ACIs.
View Article and Find Full Text PDFThe bile-gut axis and metabolic consequences of cholecystectomy.
Eur J Endocrinol
March 2024
Center for Clinical Metabolic Research, Copenhagen University Hospital-Herlev and Gentofte, DK-2900 Hellerup, Denmark.
Cholelithiasis and cholecystitis affect individuals of all ages and are often treated by surgical removal of the gallbladder (cholecystectomy), which is considered a safe, low-risk procedure. Nevertheless, recent findings show that bile and its regulated storage and excretion may have important metabolic effects and that cholecystectomy is associated with several metabolic diseases postoperatively. Bile acids have long been known as emulsifiers essential to the assimilation of lipids and absorption of lipid-soluble vitamins, but more recently, they have also been reported to act as metabolic signaling agents.
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