AI Article Synopsis
- - The study focused on young adults under 40 with elevated LDL cholesterol (LDL-C), analyzing how these levels relate to other cardiovascular disease (CVD) risk factors and their predicted long-term CVD risk.
- - It examined data from over 2,100 young adults and found that those with higher LDL-C levels also exhibited more non-LDL-C risk factors, which independently contributed to a higher predicted risk of CVD over the next 30 years.
- - The results suggest that as LDL-C levels increase, non-LDL-C risk factors tend to cluster together, highlighting the need for better management strategies for cardiovascular risks in this age group.
Article Abstract
Background: Young adults with elevated LDL-C may experience increased burden of additional cardiovascular disease (CVD) risk factors. It is unclear how much LDL-C levels, a modifiable factor, correlate with non-LDL-C CVD risk factors among young adults or how strongly these CVD risk factors are associated with long-term predicted CVD risk. We quantified clustering of non-LDL-C CVD risk factors by LDL-C among young adults to assess the association between non-LDL-C and LDL-C risk factors with predicted CVD risk in young adults.
Methods: The current analysis is a cross-sectional study of adults < 40 years with an LDL-C< 190 mg/dL participating in the National Health and Nutrition Examination Survey (NHANES) between January 2015 and March 2020. We measured the prevalence of non-LDL-C risk factors by LDL-C and association between LDL-C and non-LDL-C risk factors with predicted risk of CVD by the Predicting Risk of cardiovascular disease EVENTs (PREVENT) equations.
Results: Among 2108 young adults, the prevalence of LDL-C ≥ 130 mg/dL was 15.5%. Compared with young adults with LDL-C < 100 mg/dL, those with LDL-C 100-< 130, 130-< 160, and 160-< 190 mg/dL had greater non-LDL-C risk factors. Both LDL-C and non-LDL-C risk factors were independently associated with a 30-year risk of CVD (OR 1.05, 95% CI 1.03-1.07 and OR 1.17, 95% CI 1.12-1.23, respectively). The association of LDL-C and 30-year risk did not vary by non-LDL-C risk factor burden (p = 0.43).
Conclusion: Non-LDL-C risk factors cluster among increasing levels of LDL-C in young adults. Greater guidance on how to manage cardiovascular risk factors in young adults is needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381956 | PMC |
| http://dx.doi.org/10.1002/clc.70009 | DOI Listing |
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