AI Article Synopsis
- Scrub typhus is an infectious disease spread by chigger bites, and omadacycline is a new antibiotic that shows promise against various pathogens but has limited use for this infection.
- A case study examined patients with scrub typhus who presented symptoms like fever, ulcers, and lymph node swelling, confirming the infection through next-generation sequencing before treating with omadacycline.
- Following treatment with omadacycline, patients experienced symptom relief within two days without any negative side effects, indicating its potential as an alternative treatment for scrub typhus.
Article Abstract
Background: Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by . Omadacycline, a novel tetracycline, exhibits potent antibacterial efficacy against both typical bacteria and atypical pathogens. However, omadacycline application in the treatment of scrub typhus remains limited.
Case Summary: In the present work, we report several cases of scrub typhus, with the main clinical symptoms being fever, the formation of eschars or ulcers, local or systemic lymphadenopathy, headache, myalgia and rash. Blood samples were collected before omadacycline was administered, and infection was confirmed through targeted next-generation sequencing (tNGS). After two days of treatment, the patients' symptoms, including fever, were alleviated, with no adverse drug reactions.
Conclusion: tNGS is an effective method for diagnosing scrub typhus. Omadacycline can be considered an alternative option for antiinfective therapy in patients with infections.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263046 | PMC |
| http://dx.doi.org/10.12998/wjcc.v12.i25.5832 | DOI Listing |
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