AI Article Synopsis
- * Reliable prenatal ultrasound and molecular markers that can predict NTDs are essential for early diagnosis, which enables treatment and prevention strategies to lower disability rates.
- * This review focuses on summarizing ultrasound biomarkers identified between 11 and 13 weeks of gestation and molecular markers for diagnosing NTDs, aiming to enhance early screening methods for these conditions.
Article Abstract
Neural tube defects (NTDs) are severe congenital anomalies that result from the failure of early neural tube closure during fetal neurogenesis. They are the most common and severe congenital malformations of the central nervous system. Identifying reliable prenatal diagnostic ultrasound and molecular markers that can predict NTDs is of paramount importance. Early diagnosis of NTDs allows embryonic treatment and prevention strategies, which are crucial for reducing the disability rate associated with these malformations, reducing the burden on individuals and on society. The purpose of this comprehensive review was to summarize the ultrasound biomarkers between 11 and 13 weeks of gestation and the molecular biomarkers used in the diagnosis of NTDs, providing additional insights into early screening for NTDs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378877 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e36060 | DOI Listing |
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