AI Article Synopsis
- Central diabetes insipidus (CDI) occurs when vasopressin production is impaired, leading to excessive urination.
- A 52-year-old man with a cerebellopontine angle mass produced 8650 mL of urine despite receiving vasopressin therapy, indicating severe CDI symptoms.
- Research highlights the link between certain anesthetics, like alpha-2 agonists and sevoflurane, and increased CDI risk; desmopressin is recommended over vasopressin for prolonged surgery cases due to its longer effectiveness.
Article Abstract
Central diabetes insipidus (CDI) is a neurological pathological condition in which vasopressin synthesis has been compromised. A 52-year-old male presented with a cerebellopontine angle mass not involving the hypothalamic-pituitary axis. Despite vasopressin therapy, the patient produced a total of 8650 mL of urine, with the urine-specific gravity measured at 1.002 near hour 8. A literature review found associations with certain anesthetic drugs that have an increased incidence of CDI, including alpha-2 agonists and sevoflurane. Reports have recommended administering desmopressin over vasopressin, especially for neurosurgery cases that warrant a more extended operative period, given that desmopressin has a longer context-sensitive half-life.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379055 | PMC |
| http://dx.doi.org/10.7759/cureus.66382 | DOI Listing |
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