This study aimed to develop a nanocomposite formulation comprising umbelliferone (UMB) and molybdenum disulfide (MoS) nanosheets as a carrier, termed as the UMB-MoS nanocomposite in gel for topical delivery. MoS nanosheets were successfully synthesized via a green-hydrothermal reaction of 10 mg of ammonium molybdate and 10 mg of thiourea in 80 mL of deionized water under predetermined conditions. The UMB-MoS nanocomposite was prepared by sonicating UMB and MoS nanosheets (each of 1 mg/mL) in dimethylformamide. Scanning electron microscopy revealed crumpled nanosheets with an open-ended structure and a nanocomposite as a layered structure. The X-ray diffraction pattern revealed the amorphous nature of UMB in the UMB-MoS nanocomposite. Fourier-transform infrared spectra of the UMB-MoS nanocomposite had modified bands of the functional group, which confirmed the formation of the nanocomposite. The size and polydispersity-index (435 nm and 0.415, respectively) of the nanocomposite were within the limit for an efficient topical application. Carbopol 934 (2%) was used to prepare the UMB-MoS nanocomposite gel (F1) and UMB-Carbopol gel (F2, for comparative evaluation). The pH, spreadability, and viscosity of F1 were found to be 5.56, 5.89 g·cm/s, and 32.5 Pa-sec, respectively, which were optimal for the topical application of gel-based formulations. In vitro release characteristics of both formulations were deemed to be suitable for topical application, where F1 exhibited a biphasic drug release profile and a superior release rate of 94.8% compared to 43.5% for F2 at 24 h. In the carrageenan-induced rat paw edema model, the animal group treated with F1 demonstrated the lowest increase in paw thickness of 26.6%, which was significantly lower as compared to the F2-treated group (52.9%) and the diclofenac sodium-treated group (32.2%). Similarly, in the tail immersion method, F1 exhibited the highest peak tail withdrawal latency of 10.9 s, significantly greater than F2 (8.9 s) and standard treatment (10 s), indicating the superior analgesic activity of F1. This pioneering work introduces a novel UMB-MoS nanocomposite with promising anti-inflammatory and analgesic potentials, paving the way for further research into the biomedical applications of MoS-based nanocarriers.
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http://dx.doi.org/10.1021/acsomega.4c04252 | DOI Listing |
Chem Asian J
December 2024
University of Science and Technology Beijing, School of Materials Science and Engineering, HaiDian District,XueYuan Road 30 Beijing, 100083, Beijing, CHINA.
Gold nanoclusters (AuNCs), which are approximately 2 nm in size, exhibit distinctive photophysical and catalytic properties, but their performance is often compromised by environmental factors. To mitigate these challenges, attempts have been made to incorporate AuNCs into polymer matrices to enhance their stability. Miniemulsion polymerization has proven to be an effective method for fabricating organic-inorganic composites.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
South China University of Technology, South China Advanced Institute for Soft Matter Science and Technology, South China Advanced Institute for Soft Matter Science and Technology, 510640, Guangzhou, CHINA.
Nanoimprint lithography (NIL) has been broadly applied in the fabrication of nano-patterned polymer films for cost-efficiency and high through-put; however, the intrinsic tradeoff between mechanical strength and residual stress of polymer films significantly limits the NIL resolution while the harsh processing conditions limit its versatile applications to different substrates. Herein, 1 nm metal oxide cluster, phosphotungstic acid (PTA), is used to complexed with polyvinyl alcohol (PVA) for high-resolution NIL that can be operated at large-scale and mild conditions. The ultra-small size of PTA enables dense supramolecular interaction with PVA for the diminished crystallinity and accelerated chain dynamics that help relax the residual stress during film casting.
View Article and Find Full Text PDFACS Omega
December 2024
School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), Sector H-12, Islamabad 44000, Pakistan.
Electrochemical sensing has shown great promise in monitoring neurotransmitter levels, particularly dopamine, essential for diagnosing neurological illnesses like Parkinson's disease. Such techniques are easy, cost-effective, and extremely sensitive. The present investigation discusses the synthesis, characterization, and potential use of a cysteine-grafted Cu MOF/ZnO/PANI nanocomposite deposited on the modified glassy carbon electrode surface for nonenzymatic electrochemical sensing of dopamine.
View Article and Find Full Text PDFACS Omega
December 2024
Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Exposure to high temperatures during indoor and outdoor activities increases the risk of heat-related illness such as cramps, rashes, and heatstroke (HS). Fatal cases of HS are ten times more common than serious cardiac episodes in sporting scenarios, with untreated cases leading to mortality rates as high as 80%. Enhancing thermal comfort can be achieved through heat loss in enclosed spaces and the human body, utilizing heat transfer mechanisms such as radiation, conduction, convection, and evaporation, which do not require initial energy input.
View Article and Find Full Text PDFNat Prod Res
December 2024
Phytochemistry Department, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C, Tehran, Iran.
Plant-based nano-insecticides like provide eco-friendly pest control with low resistance risk. This study aimed to evaluate the insecticidal activity of the FeO @Carbon nanoformulation of extract with a carbon shell and pure extract against (eggs and larvae), a significant potato pest in Iran. A modified solvothermal method produced highly water-dispersible magnetite (FeO) particles, with citrate as a stabilising agent.
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