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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378351 | PMC |
| http://dx.doi.org/10.1089/rorep.2023.29007.intgw | DOI Listing |
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Background: Appropriate methods for age adjustment in associations of neuroimaging and late-life cognition is not well defined, especially among those 90+ years old. We examined how different age adjustment approaches affect the associations of MRI/PET-based regional brain markers and cognitive change in the oldest-old.
Method: LifeAfter90 is a diverse cohort study of adults ages 90+ in Northern California.
Background: Widowhood is associated with cognitive impairment, which is salient for the oldest-old, who are at high risk of cognitive decline and spousal loss. We assessed the association of marital status with cognitive decline in the LifeAfter90 Study (LA90) and examined effect modification by gender.
Method: LA90 enrolled participants aged 90+ who were long-term members of Kaiser Permanente Northern California.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: People living with Alzheimer's disease and related dementias confront numerous decisions that affect their wellbeing, as well as that of their family members. Research demonstrates the importance of family involvement in such decision making, yet there is a lack of knowledge about how patients and families work together to make decisions and how families can best provide decisional support.
Methods: Semi-structured interviews were conducted separately with 15 patients diagnosed with mild cognitive impairment (MCI) or mild dementia, identified through a National Institute on Aging-funded Alzheimer's Disease Research Center, and 14 care partners.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Best practice recommendations suggest a person close to a patient with mild cognitive impairment (MCI) or dementia be involved in their care. This person is often referred to as a "caregiver," though the term "care partner" has increasingly been used in research and care instead of "caregiver." Unlike "caregiver," "care partner" suggests a collaborative relationship between the patient and their support person, in which the patient actively participates rather than passively receives help.
View Article and Find Full Text PDFAn Explanatory Mixed-methods Study of "ICU net benefit": Triage and Trajectory for Sepsis and Acute Respiratory Failure.
Ann Am Thorac Soc
January 2025
The University of Utah School of Medicine, Division of Epidemiology, Department of Internal Medicine, Salt Lake City, Utah, United States.
Rationale: Patients with sepsis and/or acute respiratory failure are at high risk for death or long hospital stays, yet limited evidence exists to guide triage to intensive care units (ICUs) or general medical wards for the majority of these patients who do not initially require life support.
Objectives: To identify factors that influence how hospitals triage patients with capacity-sensitive conditions and those factors that may account for observed ICU relative to ward, or ward relative to ICU, benefits for such patients.
Methods: We conducted an explanatory sequential mixed-methods study.
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