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Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke. | LitMetric

Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke.

J Cereb Blood Flow Metab

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Published: December 2024

AI Article Synopsis

  • * The sigma-1 receptor (S1R) has shown potential in providing neuroprotection and may be significant in developing new stroke therapies.
  • * This review highlights how S1R agonists and antagonists could help manage issues like blood-brain barrier dysfunction, neuroinflammation, and cognitive problems after an ischemic stroke.

Article Abstract

Strokes constitute over 50% of all neurological diseases, standing as the foremost cause of physical and mental disability. Currently, there are no widely accepted gold standard treatments for ischemic strokes beyond intravenous thrombolysis and mechanical thrombectomy applied during the acute therapeutic window. Therefore, the need for novel treatments targeting crucial signaling mediators involved in ischemic stroke is of utmost importance. The sigma-1 receptor (S1R), a molecular chaperone located at mitochondria-associated endoplasmic reticulum membranes (MAM), has exhibited neuroprotective effects when modulated by synthetic and endogenous agents across various cerebrovascular diseases. In this review, we describe the emerging therapeutic role of S1R agonists and antagonists in regulating blood-brain barrier (BBB) dysfunction, neuroinflammation, and neurocognitive impairment following ischemic stroke.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571975PMC
http://dx.doi.org/10.1177/0271678X241281547DOI Listing

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