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Life sets off a cascade of machines.
Proc Natl Acad Sci U S A
January 2025
Center for Physics and Biology, Rockefeller University, New York, NY 10065.
Life is invasive, occupying all physically accessible scales, stretching between almost nothing (protons, electrons, and photons) and almost everything (the whole biosphere). Motivated by seventeenth-century insights into this infinity, this paper proposes a language to discuss life as an infinite double cascade of machines making machines. Using this simplified language, we first discuss the micro-cascade proposed by Leibniz, which describes how the self-reproducing machine of the cell is built of smaller submachines down to the atomic scale.
View Article and Find Full Text PDFInterleukin-17 and fat: Timing is everything.
Immunity
January 2025
Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, UK. Electronic address:
Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.
View Article and Find Full Text PDFEstimating the ovarian cancer CA-125 preclinical detectable phase, in-vivo tumour doubling time, and window for detection in early stage: an exploratory analysis of UKCTOCS.
EBioMedicine
January 2025
MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
Background: The ovarian cancer (OC) preclinical detectable phase (PCDP), defined as the interval during which cancer is detectable prior to clinical diagnosis, remains poorly characterised. We report exploratory analyses from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
Methods: In UKCTOCS between Apr-2001 and Sep-2005, 101,314 postmenopausal women were randomised to no screening (NS) and 50,625 to annual multimodal screening (MMS) (until Dec-2011) using serum CA-125 interpreted by the Risk of Ovarian Cancer Algorithm (ROCA).
UAV Trajectory Control and Power Optimization for Low-Latency C-V2X Communications in a Federated Learning Environment.
Sensors (Basel)
December 2024
Department of Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, Toronto, ON M5B2K3, Canada.
Unmanned aerial vehicle (UAV)-enabled vehicular communications in the sixth generation (6G) are characterized by line-of-sight (LoS) and dynamically varying channel conditions. However, the presence of obstacles in the LoS path leads to shadowed fading environments. In UAV-assisted cellular vehicle-to-everything (C-V2X) communication, vehicle and UAV mobility and shadowing adversely impact latency and throughput.
View Article and Find Full Text PDFAge of Information Analysis for Multi-Priority Queue and Non-Orthoganal Multiple Access (NOMA)-Enabled Cellular Vehicle-to-Everything in Internet of Vehicles.
Sensors (Basel)
December 2024
Qualcomm, San Jose, CA 95110, USA.
With the development of Internet of Vehicles (IoV) technology, the need for real-time data processing and communication in vehicles is increasing. Traditional request-based methods face challenges in terms of latency and bandwidth limitations. Mode 4 in cellular vehicle-to-everything (C-V2X), also known as autonomous resource selection, aims to address latency and overhead issues by dynamically selecting communication resources based on real-time conditions.
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