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Hemodynamic response of the aortic valve during dobutamine onset then progressive aortic banding.
Am J Physiol Heart Circ Physiol
January 2025
Weatherhead P.E.T. Imaging Center, McGovern Medical School at UTHealth, Houston, Texas, USA.
An increasing number of procedures over the past two decades for aortic stenosis (AS) reflects the combination of an aging population and less invasive transcatheter options. As a result, the hemodynamics of the aortic valve (AV) have gained renewed interest to understand its behavior and to optimize patient selection. We studied the hemodynamic relationship between pressure loss (ΔP) and transvalvular flow (Q) of the normal AV as well as the impact of a variable supravalvular stenosis.
View Article and Find Full Text PDFTFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway.
J Biochem Mol Toxicol
January 2025
Department of Two Branches Outside, The First People's Hospital of Yongkang, Yongkang, China.
As the most prevalent subtype of lung cancer, lung adenocarcinoma (LUAD) is closely associated with angiogenesis, which is fundamental to its progression. ADAM8 (A disintegrin and metalloproteinase 8) is an enzyme associated with tumor invasion, while its implications in LUAD angiogenesis are a field that awaits exploration. A thorough investigation into the impacts of ADAM8 on LUAD angiogenesis could contribute to the development of therapeutic drugs for LUAD.
View Article and Find Full Text PDFDetermination of the optimal method for measuring malondialdehyde in human saliva.
MethodsX
June 2025
Centre des Sciences du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, F-21000 Dijon, France.
While few methodological studies have been published on the salivary measurement of malondialdehyde (MDA), none have precisely detailed the analytical method. This work presents the development of an analytical method for MDA measurement in microvolumes of saliva samples from healthy individuals, using thiobarbituric acid derivatization and fluorescence reading of the formed compound. This method was progressively designed to meet specific constraints such as the limited sample volume available, cost-effectiveness of each assay, time required for analysis and costs.
View Article and Find Full Text PDFBackground and design of the Physical Frailty and Symptom Monitoring and Management Behaviors in Heart Failure (PRISM-HF) study: A mixed methods study.
Int J Nurs Stud Adv
June 2025
Oregon Health & Science University School of Nursing, Portland, OR, USA.
Background: Many adults with heart failure (HF) are physically frail and have worse outcomes. While the biological profile of physical frailty in HF has been examined, the behavioral profile remains unstudied. Physical frailty may impact self-care behaviors, particularly symptom monitoring and management (SMM), which in turn results in adverse outcomes.
View Article and Find Full Text PDFRevisiting the drivers of electricity consumption in designated Sub-Saharan African regions: Unraveling the role of education.
Heliyon
January 2025
Department of Statistics and Actuarial Science, Kwame Nkrumah University of Science and Technology, Ghana.
It has been established that steady supply of energy to various sectors of the economy is critical for societal growth and development. According to recent figures, barely one-third of the whole population in Sub-Saharan Africa has access to electricity, making the region the poorest in the world in terms of access to electrical power today. This stands in stark contrast to the vast energy resources that could be utilized to provide the necessary energy.
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