Objectives: To assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.
Methods: Data were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5-6 months, and multi-row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23 years. Sex-specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, p-values < 0.01 were considered statistically significant.
Results: In fully adjusted analyses, no statistically significant (p < 0.01) or suggestive (0.01 < p < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.
Conclusions: Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619560 | PMC |
| http://dx.doi.org/10.1111/jphd.12643 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Broad-based targeted lipidomic analysis of dental fluorosis population in an adult population.
Chem Phys Lipids
January 2025
College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, No.81, Meishan Road, Shushan District, Hefei City, 230032 China. Electronic address:
Dental fluorosis, as a common chronic fluoride toxicity oral disease, is mainly caused by long-term excessive intake of fluoride, which seriously affects the aesthetics and function of patients' teeth. In recent years, with the rapid development of metabolomics technology, lipidomics, as an important means to study the changes in lipid metabolism in organisms, has shown great potential in revealing the mechanisms of disease development. As a major component of cell membranes and a signaling molecule, metabolic disorders of lipids are closely related to a variety of diseases, but the specific mechanism of action in dental fluorosis is still unclear.
View Article and Find Full Text PDFMulti-indices approach for comprehensive appraisal of groundwater quality and the implication on human health in the Amaravathi basin, Southern India.
Environ Monit Assess
January 2025
Department of Water Resource and Ecosystems, IHE Delft Institute for Water Education, Westvest 7, Delft, NH, Netherlands.
Groundwater is often used directly by the public in several river basins of India. Hence, this study was carried out with the objective of assessing the quality of groundwater in the Amaravathi basin, India, using a multiple indices approach. Groundwater quality data from 96 monitoring wells were obtained from the Central Groundwater Board and used in this study.
View Article and Find Full Text PDFEvaluating major element hydrogeochemistry and fluoride occurrence in groundwater of crystalline bedrock aquifers and associated controlling factors of Eumseong basin area, South Korea.
Environ Geochem Health
January 2025
Korea Institute of Geoscience and Mineral Resources, Daejeon, 34132, Republic of Korea.
Long-term intake of high-fluoride water can cause fluorosis in bones and teeth or damage to organs. Fluoride in groundwater is primarily derived from reactions with rocks containing fluorine-related minerals, and fluoride concentrations are elevated in groundwater that has been reacting with these rocks for a long time. The purpose of this study is to investigate the origin and distribution of fluoride in groundwater and to assess the influence of various factors, including geology, on fluoride concentrations in groundwater.
View Article and Find Full Text PDFThe potential of urinary miR-200c-3p as a biomarker of fluorosis in rats.
Ecotoxicol Environ Saf
January 2025
Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. Electronic address:
Fluorine is a strong oxidizing element and excessive intake can have harmful effects, particularly on the body's calcified tissues. Recent studies have demonstrated a link between miRNA and fluorosis. This study aimed to evaluate the time-dose-effect relationship of miR-200c-3p in plasma, urine and cartilage of rats with drinking water fluorosis, and to explore its potential as a biomarker.
View Article and Find Full Text PDFEvolution characteristics and causes of iodine and fluoride in groundwater of Hengshui city in North China.
Sci Rep
December 2024
Hebei Province Collaborative Innovation Center for Sustainable Utilization of Water Resources and Optimization of Industrial Structure, Hebei GEO University, Shijiazhuang, 050031, China.
Iodine and fluoride are essential trace elements for human health, with both deficiency and excess intake impacting well-being. This study investigates the groundwater funnel area in eastern Hengshui City, utilizing groundwater level and hydrochemical data from 2014 to 2022. Hydrogeochemical methods were employed to comprehensively analyze the evolution characteristics and causes of iodine and fluoride concentrations in the funnel area.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!