AI Article Synopsis
- * These viruses replicate in the cytoplasm, possess large genomes, and can lead to severe skin and systemic diseases, with emerging interest in their effects on the central nervous system (CNS).
- * The review discusses recent findings on how poxviruses invade the CNS, the immune responses they trigger, and related clinical issues like encephalitis and myelitis.
Article Abstract
Poxviridae is a diverse family of double-stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous and systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms of CNS invasion, immune-mediated damage, and clinical manifestations such as encephalitis and myelitis. This review synthesises current knowledge on poxvirus neurotropism, highlighting pathophysiological mechanisms and clinical implications.
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| http://dx.doi.org/10.1002/rmv.2581 | DOI Listing |
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