AI Article Synopsis
- prosthetic joint infections (PJI) are difficult to treat and can arise after joint replacements, necessitating better treatment approaches and relevant animal models for research.
- The study developed a surgical protocol for hip hemiarthroplasty in Göttingen minipigs and conducted careful post-surgery evaluations, identifying challenges such as the risk of joint dislocation.
- The findings established the minipig model as a suitable option for future experiments on PJIs, showing that one pig developed a PJI linked to immune cell issues at the bone-prosthesis interface.
Article Abstract
Background: Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat infections and severe complications of joint arthroplasty. Therefore, there is a need to develop new effective treatment strategies, and animal models of high clinical relevance are needed. This study aimed to develop a detailed surgical protocol for hip hemiarthroplasty in Göttingen minipigs and a thorough post-mortem sampling protocol to pave the way for creating a minipig PJI model.
Methods: Three adult female Göttingen minipigs underwent surgery with insertion of a hip hemiarthroplasty, using the anterior approach to the hip joint. After surgery the minipigs were followed closely with daily clinical evaluation and gait scoring. Comprehensive post-mortem analyses were performed with evaluation of macroscopic lesions, microbiology, synovial fluid analysis and histology.
Results: The study resulted in the first Göttingen minipig with hip hemiarthroplasty and identified several points of awareness when inserting a hip prosthesis in minipigs, especially the high risk of joint dislocation. A spontaneous PJI occurred in one of the minipigs, revealing an impaired ability of the immune cells to reach the bacteria at the bone-prosthesis interface.
Conclusion: The present study provides a detailed description of surgical technique and post-mortem sampling and validates the suitability of the hip hemiarthroplasty minipig model for future experimental modeling of PJI.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380332 | PMC |
| http://dx.doi.org/10.1186/s13018-024-05040-z | DOI Listing |
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