Designing restoration projects requires integrating socio-economic and cultural needs of local stakeholders for enduring and just outcomes. Using India as a case study, we demonstrate a people-centric approach to help policymakers translate global restoration prioritization studies for application to a country-specific context and to identify different socio-environmental conditions restoration programs could consider when siting projects. Focusing, in particular, on poverty quantified by living standards and land tenure, we find that of the 579 districts considered here, 116 of the poorest districts have high biophysical restoration potential (upper 50th percentile of both factors). In most districts, the predominant land tenure is private, indicating an opportunity to focus on agri-pastoral restoration over carbon and forest-based restoration projects.
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http://dx.doi.org/10.1038/s44185-023-00012-8 | DOI Listing |
In Vitro Cell Dev Biol Anim
January 2025
Department of Critical Care Medicine, The Qujing NO.1 People's Hospital, Qujing, 655000, Yunnan, China.
Melatonin (MEL), functioning as a circulating hormone, is important for the regulation of ferroptosis in different health scenarios and acts as a crucial antioxidant in cardiovascular diseases. However, its specific function in ferroptosis related to myocardial ischemia-reperfusion injury (MIRI) remains to be fully elucidated. In our research, we utilized a rat model of MIRI induced by coronary artery ligation, along with a cell model subjected to hypoxia/reoxygenation (H/R).
View Article and Find Full Text PDFJ Exp Med
March 2025
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Hematopoietic stem cells (HSCs) are susceptible to replication stress, which is a major contributor to HSC defects in Fanconi anemia (FA). Here, we report that HSCs relax the global chromatin by downregulating the expression of a chromatin architectural protein, DEK, in response to replication stress. DEK is abnormally accumulated in bone marrow (BM) CD34+ cells from patients with FA and in Fancd2-deficient HSCs.
View Article and Find Full Text PDFMol Oncol
January 2025
Department of Gastrointestinal Cancer Translational Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with gastrectomy being the primary treatment option. Sepsis, a systemic inflammatory response to infection, may influence tumor growth by creating an immunosuppressive environment conducive to cancer cell proliferation and metastasis. Here, the effect of abdominal infection on tumor growth and metastasis was investigated through the implementation of a peritoneal metastasis model and a subcutaneous tumor model.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20) mitochondrial-derived vesicles (MDVs). The role of MDVs in DFU is yet to be reported.
View Article and Find Full Text PDFEcol Appl
January 2025
Ecology labs, Department of Zoology, Central University of Kerala, Periya, Kerala, India.
Wild solitary bees face a host of challenges from the simplification of landscapes and biodiversity loss to invasive species and urbanization. Pollinator researchers and restoration workers thus far gave much attention to increase flower cover to reduce the impact of these anthropogenic pressures. Over 30% of bee species need nonfloral resources such as leaves and resin for their survival and reproduction.
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