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[Expression and Prognostic Significance of B-cell Development-Related Genes in Children with Acute B Lymphoblastic Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Shaanxi Institute for Pediatric Diseases, Shaanxi Provincial Key Laboratory of Children's Health and Diseases, Xi'an Children's Hospital, Shaanxi Province, China.
Objective: To analyze the expression of B-cell development-related genes in acute B lymphoblastic leukemia (B-ALL), and to explore the relationship between B-cell development-related genes and the prognosis of B-ALL patients.
Methods: The GEO and TARGET databases were integrated to analyze the differential expression of B-cell development-related genes between the healthy persons and B-ALL patients and their differential expression in the B-ALL relapse and non-relapse groups. Cox single factor regression and Lasso regression were used to constructe a B-ALL specific prognosis model of B-cell development-related genes.
Physiological and molecular response mechanisms of tomato seedlings to cadmium (Cd) and lead (Pb) stress.
PeerJ
December 2024
Lingnan Normal University, Zhanjiang, China.
Article Synopsis
- The study examined how cadmium (Cd) and lead (Pb) stress affect tomato seedlings, focusing on growth and molecular responses.
- Results showed that exposure to both metals significantly boosted soluble sugar and proline levels while increasing antioxidant enzyme activities, indicating a stress response.
- The findings highlight potential gene regulation involved in metal tolerance, suggesting future research could enhance plant resilience against heavy metal contamination.
Liver transcriptomics-metabolomics integration reveals biological pathways associated with fetal programming in beef cattle.
Sci Rep
November 2024
Department of Animal Science, Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga, 13635-900, SP, Brazil.
We investigated the long-term effects of prenatal nutrition on pre-slaughter Nelore bulls using integrative transcriptome and metabolome analyses of liver tissue. Three prenatal nutritional treatments were administered to 126 cows: NP (control, mineral supplementation only), PP (protein-energy supplementation in the third trimester), and FP (protein-energy supplementation throughout pregnancy). Liver samples from 22.
View Article and Find Full Text PDFSpatial metabolomics, LC-MS and RNA-Seq reveal the effect of red and white muscle on rabbit meat flavor.
Meat Sci
January 2025
College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China. Electronic address:
Meat quality is a key factor influencing consumer purchasing decisions. Muscle composition consists of various types of myofibers (type I and type IIa, IIb, IIx myofibers), and the relative composition of fiber types has a significant impact on the overall biochemical properties and flavor of fresh meat. However, the relationship between biochemical changes in myofibers and their impact on meat quality remains underexplored.
View Article and Find Full Text PDFODC1, a key enzyme in polyamine metabolism, plays a regulatory role in B cell differentiation.
Asian J Surg
September 2024
Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), China.
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