A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency. | LitMetric

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.

Clin Immunol

Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.

Published: November 2024

AI Article Synopsis

  • - Selective IgA deficiency (SIgAD) is the most common type of inherited immune disorder, but previous studies have struggled to find specific genetic variants due to small sample sizes.
  • - Researchers conducted a meta-analysis of existing Genome-Wide Association Studies (GWAS), discovering four new common genetic variants linked to SIgAD and confirming connections to genes associated with other inherited immune disorders.
  • - By analyzing the genetic links between SIgAD, serum IgA levels, asthma, and rheumatoid arthritis, the study identified an additional 18 genetic variants, raising the total to 27 and supporting the idea that SIgAD has a complex genetic basis.

Article Abstract

Selective IgA deficiency (SIgAD) is the most common inborn error of immunity (IEI). Unlike many IEIs, evidence of a role for highly penetrant rare variants in SIgAD is lacking. Previous SIgAD studies have had limited power to identify common variants due to their small sample size. We overcame this problem first through meta-analysis of two existing GWAS. This identified four novel common-variant associations and enrichment of SIgAD-associated variants in genes linked to Mendelian IEIs. SIgAD showed evidence of shared genetic architecture with serum IgA and a number of immune-mediated diseases. We leveraged this pleiotropy through the conditional false discovery rate procedure, conditioning our SIgAD meta-analysis on large GWAS of asthma and rheumatoid arthritis, and our own meta-analysis of serum IgA. This identified an additional 18 variants, increasing the number of known SIgAD-associated variants to 27 and strengthening the evidence for a polygenic, common-variant aetiology for SIgAD.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2024.110356DOI Listing

Publication Analysis

Top Keywords

common-variant associations
8
selective iga
8
iga deficiency
8
sigad-associated variants
8
serum iga
8
sigad
6
variants
5
leveraging pleiotropy
4
pleiotropy identifies
4
identifies common-variant
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!