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Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1. | LitMetric
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Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1.

Kexin Hu Yu Cao

Structure

Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai 200125, China; Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Electronic address:

Published: September 2024

Fumonisin B1 (FB1) targets sphingolipid biosynthesis, inhibiting ceramide synthases. In this issue of Structure, Zhang et al. determined the cryoelectron microscopic structures of yeast ceramide synthase in complex with FB1 and its acylated derivative, acyl-FB1, revealing a two-step "ping-pong" mechanism for the N-acylation of FB1 and how it inhibits ceramide synthase.

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http://dx.doi.org/10.1016/j.str.2024.08.010DOI Listing

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