AI Article Synopsis
- The placenta plays a key role in managing nutrient exchange between the mother and fetus, and its development is influenced by nutritional factors.
- The research by Yu et al. identifies the intertwined metabolic and epigenetic changes involved in the formation of syncytiotrophoblasts (syncytialization).
- They highlight that a specific metabolite, acetyl-CoA, which is affected by glucose metabolism, is essential for this process.
Article Abstract
While the placenta regulates nutritional exchange between mother and fetus, Yu et al. reveal that human placental development is itself nutrient-sensitive. They elucidate entwined metabolic and epigenetic transitions driving syncytialization and pinpoint a requirement for the metabolite acetyl-CoA, which is sensitive to glucose metabolism.
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| http://dx.doi.org/10.1016/j.stem.2024.08.003 | DOI Listing |
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