AI Article Synopsis
- 2-deoxy-D-glucose (2DG) has shown potential as an antiseizure treatment in various seizure models, especially for conditions like status epilepticus (SE).
- Recent preclinical toxicological studies indicate that a single intravenous dose of 2DG may be safe for use in treating acute SE and acute repetitive seizures (ARS).
- These findings suggest that 2DG could be a viable option for managing seizures, pending further research.
Article Abstract
2-deoxy-D-glucose (2DG) has been proposed as a potential antiseizure treatment based on seizure suppressive actions in multiple acute and chronic seizure models, including models of status epilepticus (SE). Here we summarize recently completed preclinical toxicological studies of single doses of an intravenous formulation of 2DG supporting potential safety of 2DG for acute treatment of SE and acute repetitive seizures (ARS).
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| http://dx.doi.org/10.1016/j.yebeh.2024.110004 | DOI Listing |
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