In unsupervised domain adaptive object detection, learning target-specific features is pivotal in enhancing detector performance. However, previous methods mostly concentrated on aligning domain-invariant features across domains and neglected integrating the specific features. To tackle this issue, we introduce a novel feature learning method called Joint Feature Differentiation and Interaction (JFDI), which significantly boosts the adaptability of the object detector. We construct a dual-path architecture based on we proposed feature differentiate modules: One path, guided by the source domain data, utilizes multiple discriminators to confuse and align domain-invariant features. The other path, specifically tailored to the target domain, learns its distinctive characteristics based on pseudo-labeled target data. Subsequently, we implement an interactive enhanced mechanism between these paths to ensure stable learning of features and mitigate interference from pseudo-label noise during the iterative optimization. Additionally, we devise a hierarchical pseudo-label fusion module that consolidates more comprehensive and reliable results. In addition, we analyze the generalization error bound of JFDI, which provides a theoretical basis for the effectiveness of JFDI. Extensive empirical evaluations across diverse benchmark scenarios demonstrate that our method is advanced and efficient.
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http://dx.doi.org/10.1016/j.neunet.2024.106682 | DOI Listing |
Int J Equity Health
January 2025
JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Background: South Asians living in urbanized settings are facing disproportionate cardiovascular burden largely attributable to modifiable risk factors. Given the rapid surge in South Asian population in Hong Kong, this study aims to identify and distinguish clusters of cardiovascular risk profiles among community-dwelling South Asian adults.
Methods: Between June 2022 and December 2023, 1181 South Asian adults were recruited through territory-wide outreach health assessments on lifestyle, psychological distress, obesity, clinical cardiovascular conditions, and sociodemographic factors.
Nat Commun
January 2025
National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Epitranscriptomic modifications, particularly N6-methyladenosine (mA), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation. Traditional computational methods for detecting mA from Nanopore direct RNA sequencing (DRS) data are constrained by their reliance on experimentally validated labels, often resulting in the underestimation of modification sites. Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing read-level annotations.
View Article and Find Full Text PDFHosp Pract (1995)
January 2025
Education Development Center, Iran University of Medical Sciences, Tehran, Iran.
Aims: This study investigates the differences in patient demographics and outcomes between teaching and non-teaching hospitals in Iran. By analyzing these differences, it aims to provide useful information for policymakers to optimize resource allocation, improve patient care, and balance educational and service delivery goals in teaching hospitals.
Materials And Methods: In this cross-sectional investigation, both teaching and non-teaching general hospitals were examined.
Nat Commun
January 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
Oxidative stress plays a critical role in postmenopausal osteoporosis, yet its impact on osteoblasts remains underexplored, limiting therapeutic advances. Our study identifies phospholipid peroxidation in osteoblasts as a key feature of postmenopausal osteoporosis. Estrogen regulates the transcription of glutathione peroxidase 4 (GPX4), an enzyme crucial for reducing phospholipid peroxides in osteoblasts.
View Article and Find Full Text PDFComput Biol Med
January 2025
IMT Atlantique, Lab-STICC, UMR CNRS 6285, team RAMBO, F-29238 Brest, France.
Rehabilitation is the process of helping people regain or improve lost or impaired function due to injury, illness, or disease. To assist in tracking the progress of patients undergoing rehabilitation, this paper proposes a lightweight graph-based deep-learning model for the automatic assessment of physical rehabilitation exercises. The model takes as input the 3D skeleton sequence of a patient performing a movement and outputs a continuous quality score, as a means for patient supervision that could complement or even substitute the need for ordinary clinical exams.
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