AI Article Synopsis
- Hailey-Hailey disease (HHD) is a rare skin condition caused by mutations in the ATP2C1 gene, and previous research has suggested a possible link to heart disease, although its exact systemic effects remain unclear.
- * The study aimed to assess the association between HHD and heart disease using a Swedish population-based cohort, matching 342 HHD patients with controls without the disease.
- * Results indicated that individuals with HHD had a higher risk of arrhythmia but did not show increased risks for myocardial infarction or heart failure, marking the first evidence of a potential systemic effect of HHD beyond the skin.
Article Abstract
Background: Hailey-Hailey disease (HHD) is a rare autosomal dominant skin disease caused by mutations in the ATP2C1 gene, which encodes the secretory Ca2+/Mn2+-ATPase (SPCA1) pump in the Golgi apparatus. Although ATP2C1 is ubiquitously expressed in the body, possible extracutaneous manifestations of HHD are unknown. However, dysfunction of the Golgi apparatus not specifically coupled to ATP2C1 has been associated with heart disease.
Objective: To investigate the association between HHD and common heart disease in a Swedish, population-based cohort.
Methods: We conducted a population-based cohort study based on a linkage of Swedish nationwide registers to investigate the relationship between HHD and heart disease. We have been granted ethical approval from the Swedish Ethical Review Authority to conduct this study. The patients in this manuscript have given written informed consent to the publication of their case details. A total of 342 individuals with an ICD-10 diagnosis of HHD (Q82.8E) were identified and matched with randomly selected comparison individuals without HHD on a 1:100 ratio. Furthermore, in a separate clinical cohort we matched 23 HHD patients for age, sex, and BMI with control subjects to examine electrocardiogram parameters, electrolytes, and cardiovascular biomarkers.
Results: Compared with individuals without HHD, individuals with HHD had an excess risk of arrhythmia (RR 1.4, CI 1.0-2.0), whereas no increased risks of myocardial infarction (RR 1.1, CI 0.6-1.7) or heart failure (RR 1.0, CI 0.6-1.6; Table 1) were found. We found no difference in ECG parameters, cardiovascular biomarkers, and electrolytes in the clinical subset.
Conclusion: This study reveals that HHD is associated with an increased risk of arrhythmia and represents the first data of any extracutaneous comorbidity in HHD. Thus, HHD may be a systemic disease. Our findings also shed light on the importance of the Golgi apparatus' Ca2+/Mn2+ homeostasis in common heart disease.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379163 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0309482 | PLOS |
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