This work explores if behaviour-based asymmetries are likely to impact deal valuation in the life sciences by examining positive public sentiment as a proxy for market behaviour when negotiating under asymmetric conditions to examine heterogeneity in research & development collaboration (RDC) deal data. We use public sentiment as a proxy for behaviour along with stage of development-based RDC deal data to search for latent classes in the deal data using finite mixture modelling. The analysis reveals a nuanced picture: public sentiment emerges as a significant predictor of deal value, but only for approximately 15% of the data set. This subset exclusively includes firms in the Preclinical stage, where projects have moved past discovery but are yet to commence human studies. Interestingly, the research finds that sentiment's impact on deal valuation is particularly pronounced in this stage, suggesting heightened market sensitivity. With recent research demonstrating that knowledge asymmetry and behaviour impact valuation volatility, we take this further by capturing latent classes within the data which demonstrates how behaviour is most influential in deal pricing considerations. We argue that our research demonstrates the impact of asymmetry and market behaviour on a subset of RDCs where products are known, but likelihood of success is difficult to determine.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379164 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307116 | PLOS |
J Appl Gerontol
January 2025
The Hebrew University-Hadassah, Jerusalem, Israel.
The study identified care network types comprising informal and formal care providers during the end-of-life period, and examined their relationship with home deaths. End-of-life interviews were conducted with proxies during the two waves of the COVID-19 pandemic in the Survey of Health, Ageing and Retirement in Europe (SHARE). The sample included 486 participants who passed away during the pandemic and received care during their final year.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Obstetrics and Gynaecology, Croydon University Hospital, Croydon CR7 7YE, UK.
The aim of this study is to validate a uniform method for measuring perineal descent which can be used for different imaging methods, to establish cut-off values for this measurement, and to assess diagnostic test accuracy (DTA) of imaging techniques using these cut-off values. Secondly, the study aims to correlate perineal descent to symptoms, signs and imaging findings in women with obstructed defaecation syndrome (ODS) to assess its clinical relevance. Cross-sectional study of 131 women with symptoms of ODS.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of General Practice, The First Dongguan Affiliated Hospital at Guangdong Medical University, Dongguan, 523808, China.
Background: The association between social capital and trajectories of cognitive function (CF) is still unclear among older adults in mainland China. The present study aims to examine the association using a longitudinal cohort from the Ningxia Healthy Aging Cohort.
Methods: Four waves of longitudinal data were abstracted to identify the CF trajectories using the conditional latent class growth model (LCGM).
Prev Med
January 2025
Department of Sociology, McGill University, 855 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2T7.
Objectives: Indigenous peoples in Canada endure health inequalities and cultural erosion due to colonial legacies. This study examines the relationship between ethnic belonging and chronic disease patterns among three Indigenous groups: First Nations, Inuit, and Métis.
Methods: We analyzed data from the 2017 Indigenous Peoples Survey of Canada, performing latent class analysis to identify distinct classes among 12 chronic disease indicators.
Arch Med Res
January 2025
Center for Health Systems Research, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico. Electronic address:
Background: Longitudinal analysis of multimorbidity (MM) from a holistic approach to the aging population is necessary to guide medical care.
Aims: To estimate the probability of transition between different MM patterns and the "death" stage and to characterize the socioeconomic, health, behavioral, and functional dimensions of MM patterns from a syndemic perspective.
Methods: A cohort of 7,120 people ≥50 from the Mexican Health and Aging Study and mortality data at 11 and 17 years of follow-up were analyzed using the latent class approach.
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