AI Article Synopsis
- SAMHD1 is a protein that helps prevent HIV-1 infection in certain immune cells.
- It works by lowering the levels of dNTPs, which are needed for HIV-1 to make copies of its DNA.
- New research shows that some changes to SAMHD1 can keep it from doing its job of stopping HIV-1, so scientists need to study it more to find new ways to fight the virus.
Article Abstract
SAMHD1 is an intrinsic limiting factor that effectively prevents HIV-1 infection in macrophages, dendritic cells, and resting CD4+ T cells. Extensive studies have underscored the indispensable role of the dNTPase activity of SAMHD1 in its antiviral function by primarily depleting dNTPs in quiescent cells, thereby impeding HIV-1 cDNA synthesis. However, recent advancements in understanding posttranslational modifications of SAMHD1 have revealed specific modification site mutants that maintain their ability to reduce dNTP levels while impairing the inhibition of HIV-1 replication. Thus, the precise anti-HIV-1 mechanism of SAMHD1 remains enigmatic, necessitating a comprehensive understanding of the underlying mechanisms to develop novel therapeutic strategies targeting its antiviral activity. Recent findings by Guo et al. shed light on the role of SAMHD1 as an HIV-1 core sensor in suppressing HIV-1 infection after viral cDNA synthesis through its interaction with MX2 (H. Guo, W. Yang, H. Li, J. Yang, et al., mBio 15:e01363-24, 2024, https://doi.org/10.1128/mbio.01363-24).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481905 | PMC |
| http://dx.doi.org/10.1128/mbio.01675-24 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!