Triflic Anhydride-Mediated Approach to Furo[3,2-]furans from Diacetonide Protected Furanoses.

Trifluoromethanesulfonic anhydride (TfO) exhibits excellent reactivity as an electrophile, serving as a highly versatile reagent in diverse chemical transformations. Herein, we report an operationally simple, efficient, unique, and practical one-step strategy for synthesizing diverse valuable structures bearing furo[3,2-]furans core leveraging TfO's promoted reactivity of nitriles with diacetonide protected furanose. Furthermore, we demonstrate the potential of furo[3,2-]furan as a precursor for complex structures through 1,3-dipolar cycloaddition.