Pancreatic cancer (PC) is a challenging and heterogeneous disease with a high mortality rate. Despite advancements in treatment, the prognosis for PC patients remains poor, with a high chance of disease recurrence. Biomarkers are crucial for diagnosing cancer, predicting patient prognosis and selecting treatments. However, the current lack of effective biomarkers for PC could contribute to the insufficiency of existing treatments. These findings underscore the urgent need to develop novel strategies to fight this disease. This study utilized multiple comprehensive bioinformatic analyses to identify potential therapeutic target genes in PC, focusing on histone lysine demethylases (KDMs). We found that high expression levels of KDM family genes, particularly KDM1A, KDM5A and KDM5B, were associated with improved overall survival in the cohort. Furthermore, the infiltration of various immune cells, including B cells, neutrophils, CD8 T cells, dendritic cells, and macrophages, was positively correlated with KDM1A, KDM5A, and KDM5B expression. Moreover, MetaCore pathway analysis revealed interesting connections between KDM1A and the cell cycle and proliferation, between KDM5A and DNA damage and double-strand break repair through homologous recombination, and between KDM5B and WNT/β-catenin signaling. These findings suggest that KDM1A, KDM5A and KDM5B may serve as promising biomarkers and therapeutic targets for PC, a disease of high importance due to its aggressive nature and urgent need for novel biomarkers to improve diagnosis and treatment.
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http://dx.doi.org/10.7150/ijms.96134 | DOI Listing |
Int J Med Sci
September 2024
Department of Biological Science and Technology, China Medical University, Taichung 40676, Taiwan.
Mol Biol Rep
February 2024
CRESCO, Centre for Embryology and Healthy Development, Department of Biotechnology, Inland Norway University of Applied Sciences, Hamar, Norway.
Background: Reliable RT-qPCR results are dependent on appropriate normalisation. Oocyte maturation studies can be challenging in this respect, as the stage of development can distinctively affect reference gene transcript abundance. The aim of this study was to validate the use of reference genes in oocyte in vitro maturation RT-qPCR studies, and thereafter, examine the abundance of transcripts supporting histone modification during oocyte and early embryo development in oocytes of contrasting quality.
View Article and Find Full Text PDFBiology (Basel)
May 2023
College of Biology and Environment, Zhejiang Wanli University, Ningbo 315100, China.
() is a commonly cultivated turtle species with a habit of hibernation. To study the changes in histone expression and methylation of during hibernation induction, a model was established by artificial induction. Physiological and metabolic indices were measured, and the expression and localization of histone (, , , , and ) and methylation-related genes (, , , , , and ) were measured by quantitative PCR, immunohistochemistry, and Western blot analysis.
View Article and Find Full Text PDFJ Periodontal Res
April 2023
Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
FEBS Lett
April 2023
Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, UK.
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