AI Article Synopsis

  • This study looked at how to better grade prostate cancer using a new machine learning model that combines different types of medical data.
  • They analyzed information from 146 patients who had specific imaging tests before surgery and created five different models to see which worked best.
  • The best model, called the random forest model, outperformed the usual grading method, helping doctors find patients at higher risk for more personalized treatment.

Article Abstract

: This study aims to assess whole-mount Gleason grading (GG) in prostate cancer (PCa) accurately using a multiomics machine learning (ML) model and to compare its performance with biopsy-proven GG (bxGG) assessment. : A total of 146 patients with PCa recruited in a pilot study of a prospective clinical trial (NCT02659527) were retrospectively included in the side study, all of whom underwent Ga-PSMA-11 integrated positron emission tomography (PET) / magnetic resonance (MR) before radical prostatectomy (RP) between May 2014 and April 2020. To establish a multiomics ML model, we quantified PET radiomics features, pathway-level genomics features from whole exome sequencing, and pathomics features derived from immunohistochemical staining of 11 biomarkers. Based on the multiomics dataset, five ML models were established and validated using 100-fold Monte Carlo cross-validation. : Among five ML models, the random forest (RF) model performed best in terms of the area under the curve (AUC). Compared to bxGG assessment alone, the RF model was superior in terms of AUC (0.87 vs 0.75), specificity (0.72 vs 0.61), positive predictive value (0.79 vs 0.75), and accuracy (0.78 vs 0.77) and showed slightly decreased sensitivity (0.83 vs 0.89) and negative predictive value (0.80 vs 0.81). Among the feature categories, bxGG was identified as the most important feature, followed by pathomics, clinical, radiomics and genomics features. The three important individual features were bxGG, PSA staining and one intensity-related radiomics feature. : The findings demonstrate a superior assessment of the developed multiomics-based ML model in whole-mount GG compared to the current clinical baseline of bxGG. This enables personalized patient management by identifying high-risk PCa patients for RP.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373617PMC
http://dx.doi.org/10.7150/thno.96921DOI Listing

Publication Analysis

Top Keywords

whole-mount gleason
8
gleason grading
8
grading prostate
8
prostate cancer
8
radical prostatectomy
8
bxgg assessment
8
genomics features
8
model
5
bxgg
5
features
5

Similar Publications

Ga-PSMA PET/CT-Based Model Predicts Perineural Invasion of Prostate Cancer with Whole-Mount Sections.

Mol Imaging Biol

December 2024

Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute of Urology Nanjing University, Jiangsu, China.

Purpose: To develop a novel risk model incorporating Ga-PSMA PET/CT parameters for prediction of perineural invasion (PNI) of prostate cancer (PCa).

Methods: The study retrospectively enrolled 192 PCa patients with preoperative multiparametric MRI, Ga-PSMA PET/CT and radical specimen. Imaging parameters were derived from both mpMRI and PET/CT images.

View Article and Find Full Text PDF

Dynamic contrast enhancement (DCE) imaging is a valuable sequence of multiparametric magnetic resonance imaging (mpMRI). A DCE sequence enhances the vasculature and complements T2-weighted (T2W) and Diffusion-weighted imaging (DWI), allowing early detection of prostate cancer. However, DCE assessment has remained primarily qualitative.

View Article and Find Full Text PDF

The impact of benign tissue within cancerous regions in the prostate: Characterizing sparse and dense prostate cancers on whole-mount histopathology and on multiparametric MRI.

Magn Reson Imaging

December 2024

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA; The Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, Berkeley, CA 94720, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Purpose: To establish the incidence, size, zonal location and Gleason Score(GS)/Gleason Grade Group(GG) of sparse versus dense prostate cancer (PCa) lesions and to identify the imaging characteristics of sparse versus dense cancers on multiparametric MRI (mpMRI).

Methods: Seventy-six men with untreated PCa were scanned prior to prostatectomy with endorectal-coil 3 T MRI including T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced MRI. Cancerous regions were outlined and graded on the whole-mount, processed specimens, with tissue compositions estimated.

View Article and Find Full Text PDF
Article Synopsis
  • This study looked at how to better grade prostate cancer using a new machine learning model that combines different types of medical data.
  • They analyzed information from 146 patients who had specific imaging tests before surgery and created five different models to see which worked best.
  • The best model, called the random forest model, outperformed the usual grading method, helping doctors find patients at higher risk for more personalized treatment.
View Article and Find Full Text PDF

Comparison of data fusion strategies for automated prostate lesion detection using mpMRI correlated with whole mount histology.

Radiat Oncol

July 2024

Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: In this work, we compare input level, feature level and decision level data fusion techniques for automatic detection of clinically significant prostate lesions (csPCa).

Methods: Multiple deep learning CNN architectures were developed using the Unet as the baseline. The CNNs use both multiparametric MRI images (T2W, ADC, and High b-value) and quantitative clinical data (prostate specific antigen (PSA), PSA density (PSAD), prostate gland volume & gross tumor volume (GTV)), and only mp-MRI images (n = 118), as input.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!