AI Article Synopsis
- This study uses bioinformatics to identify genes that are commonly upregulated in both chemical burns and gastric cancer.
- The researchers analyzed gene sets from the Gene Expression Omnibus (GEO) and used various tools to find shared genes and visualize their interactions.
- Two key genes, ALOX5AP and SERPINB2, were identified as linked to both conditions, and five potential drugs were suggested for treating gastric cancer after chemical burns.
Article Abstract
Introduction: The present study employs bioinformatics tools to identify shared upregulated genes between chemical burns and gastric cancer.
Methods: Gene Expression Omnibus (GEO) retrieved gene sets for this investigation. GSEs with value less than 0.05 and LOG fold change (FC) greater than 1 were valid and upregulated. Gastric cancer and chemical burn common elevated genes were found using Venn diagram online tools. In the second stage, the "string" visualized gastric cancer elevated genes network, and non-coding RNAs were deleted, and "interaction" greater than 1 was examined to choose important gene nodes. Next, they explored the String gene-interaction network for common genes. To determine the most interacting genes, Gephi (V 0.9.7) used "betweenness centrality" greater than "0" to evaluate the twenty-gene network. TISIDB and drug banks provide gene-related medications.
Results: In the present study, two genes, including ALOX5AP and SERPINB2, were obtained, with the highest centrality among chemical burns and gastric cancer shared genes. Additionally, the current study presented five drugs, including Urokinase, Tenecteplase, DG031, AM103, and Fiboflapon, which can have predicted effects on gastric cancer following chemical burns.
Conclusion: According to current in-silicon analyses, ALOX5AP and SERPINB2 are linked genetic keys between gastric chemical burn and cancer. Considering that burn is an environmental factor that leads to the upregulation of the two genes thus, the chemical burn can be related to the incidence of gastric cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374194 | PMC |
| http://dx.doi.org/10.1097/MS9.0000000000002240 | DOI Listing |
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