Herein, a gold-catalyzed alkyne oxidative cyclization/Mannich-type addition cascade reaction of ynamides with 1,3,5-triazinanes in the presence of a Brønsted acid has been presented. A class of functionalized fluorenes bearing a quaternary carbon center was synthesized directly with moderate to excellent yields via in situ formed α-oxo carbenes using quinoline -oxide as the oxidant under mild reaction conditions.
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| http://dx.doi.org/10.1021/acs.joc.4c01784 | DOI Listing |
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