Moyamoya disease, characterized by basal cerebral artery obstruction, was studied for differential protein expression to elucidate its pathogenesis. Proteomic analysis of cerebrospinal fluid from 10 patients, categorized by postoperative angiography into good and poor prognosis groups, revealed 46 differentially expressed proteins. Notably, cadherin 18 (CDH18) was the most significantly upregulated in the good prognosis group. In addition, the expression of cadherin 18 (CDH18) and phenotypic transformation-related proteins were measured by qRT-PCR and western blot. The effects of CDH18 in vascular smooth muscle cells were detected by CCK-8, EdU, transwell and wound healing assays. The overexpression of CDH18 in vascular smooth muscle cells (VSMCs) was found to inhibit proliferation, migration, and phenotypic transformation. These findings suggest CDH18 as a potential therapeutic target in moyamoya disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378584 | PMC |
| http://dx.doi.org/10.1186/s13062-024-00522-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Significant miRNAs as Potential Biomarkers to Differentiate Moyamoya Disease From Intracranial Atherosclerotic Disease.
J Clin Neurol
March 2025
Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
Integrated bulk RNA sequencing and mass cytometry analysis reveal the circulating immune landscape in ischemic and hemorrhagic Moyamoya disease.
BMC Immunol
March 2025
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Background: Moyamoya disease (MMD) is increasingly recognized as being influenced by chronic inflammation, with circulating immune cells playing a role in its progression. However, research on the immune characteristics of different MMD subtypes is limited. This study aims to compare the peripheral immune profiles of ischemic and hemorrhagic MMD patients.
View Article and Find Full Text PDFClinical Outcomes and Stroke Recurrence in Moyamoya Disease Post-Revascularization: A Retrospective Analysis.
J Pharm Bioallied Sci
December 2024
Medical Intern, College of Medicine, King Saud Bin Abdulaziz University of National Guard, Riyadh, Saudi Arabia.
Objectives: This study aimed to assess the clinical characteristics, treatment outcomes, and recurrence risks in moyamoya disease (MMD) patients, focusing on the impact of revascularization and antiplatelet therapy.
Materials And Methods: Forty-six MMD patients were analyzed. Data on demographics, clinical characteristics, treatment outcomes, and recurrence rates of ischemic and hemorrhagic strokes were collected.
Predictors of Perioperative Stroke in Patients with Ischemic-type Moyamoya Disease Treated with Surgical Revascularization: A retrospective multicenter study.
J Stroke Cerebrovasc Dis
March 2025
Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Electronic address:
Introduction: Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the internal carotid arteries and the development of collateral moyamoya vessels. Surgical revascularization is commonly used to prevent future ischemic events in ischemic-type MMD, but there remains a high rate of stroke perioperatively. This study aims to analyze the predictive factors for perioperative stroke in patients with ischemic-type MMD undergoing surgical revascularization using a large multicenter database.
View Article and Find Full Text PDFMulti-delay arterial spin labeling using a variable repetition time scheme in Moyamoya disease: Comparison with single-delay arterial spin labeling.
Eur J Radiol
March 2025
Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Purpose: To present a multi-delay arterial spin labeling (ASL) protocol that obtains the cerebral blood flow (CBF) considering the arterial transit time (ATT), and to assess the correlations with an iodine-123-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (I-IMP SPECT) reference standard between multi-delay ASL and single-delay ASL in patients with Moyamoya disease.
Method: We retrospectively analyzed the images of 23 patients with Moyamoya disease (4-73 years, 5 men, 18 women), each of whom was imaged with 10-delay ASL using the variable repetition time (TR) scheme, single-delay ASL, and SPECT. Pearson correlation coefficients were calculated between the CBF values of each ASL and SPECT in the three divisions of the ATT, which we categorized as fast, normal, and slow regions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!