AI Article Synopsis
- This study looked at teenagers with major depressive disorder (MDD) to see how often they also have psychotic symptoms, which can make them see or hear things that aren't there.
- They found that about 22.6% of these teens had psychotic symptoms, and certain factors like age and hormone levels were linked to this.
- The researchers suggest that doctors should pay closer attention to hormone levels, like prolactin and thyroid hormones, in depressed teens who show psychotic symptoms.
Article Abstract
Objective: Major depressive disorder (MDD) is often accompanied by psychotic symptoms. However, few studies have examined the relationship between psychotic symptoms and endocrine factors in adolescent patients with MDD. Therefore, this study aimed to investigate the prevalence and related endocrine clinical factors of psychotic symptoms in Chinese adolescent patients with MDD.
Methods: In total, 601 patients (aged 12-18) with MDD were recruited. The Patient Health Questionnaire - 9 items (PHQ - 9) was utilized for assessing depressive symptoms. Psychotic symptoms were assessed through clinical interviews. Prolactin (PRL), thyroid-stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), and free thyroxine (FT4) were also measured.
Results: The incidence of psychotic symptoms in adolescent patients with MDD was 22.6%. The findings demonstrated that age, self-harming behavior, PHQ-9 score, FT4, and normalized PRL were independently associated with psychotic symptoms in patients with MDD (All p < 0.05).
Conclusions: PRL and FT4 levels are more likely to be abnormally elevated in major depressive adolescents with psychotic symptoms. Prolactin and thyroid hormones in patients with MDD should be paid more attention.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376036 | PMC |
| http://dx.doi.org/10.1186/s12888-024-06023-4 | DOI Listing |
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