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http://dx.doi.org/10.1002/cyto.b.22205 | DOI Listing |
Cytometry B Clin Cytom
September 2024
Department of Hematopathology, UT MD Anderson Cancer Center, Houston, Texas, USA.
Cancer Sci
January 2011
Department of Hematology and Oncology, Campus Benjamin Franklin, Charité, University Hospital Berlin, Berlin, Germany.
The important role of insulin-like growth factor binding protein 7 (IGFBP7) as a tumor suppressor in solid tumors has been revealed in several studies. Interestingly, in a recent study IGFBP7 was also shown to be aberrantly expressed in acute leukemia. Moreover, in acute T-lymphoblastic leukemia (T-ALL), high IGFBP7 expression predicts primary therapy resistance.
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