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The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer.
Nat Commun
September 2024
Department of Gastric Surgery, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.
Article Synopsis
- Younger premenopausal women show a higher likelihood of developing ovarian metastases from gastric cancer compared to other cancers, but the exact biological processes are not fully understood.
- Researchers used single-cell RNA sequencing on tumor samples from gastric cancer patients with ovarian metastases, discovering that ovarian fibroblasts express high levels of estrogen receptors and midkine, which facilitates communication with tumor cells through a specific signaling pathway.
- The study suggests that estrogen influences ovarian fibroblasts to secrete midkine, which promotes gastric cancer cell migration and invasion, potentially leading to new treatment approaches for ovarian metastases in gastric cancer.
Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas.
Gut
December 2024
Translational Molecular Pathology, UTMDACC, Houston, Texas, USA
Article Synopsis
- Oncogenic mutations in and are key drivers of intraductal papillary mucinous neoplasms (IPMNs), which can lead to pancreatic cancer, and prior research showed that these mutations lead to cystic lesions in a specific mouse model.
- The study investigated how these mutations affect cell characteristics and gene expression using advanced transcriptional profiling techniques and CRISPR screens to find potential weaknesses in cells with these mutations.
- The findings revealed that co-expression of and led to a distinct gene signature and increased reliance on glycolysis, suggesting that targeting metabolic changes could be a promising strategy for treating or preventing IPMNs.
Demographic Comparison of the Burden of Endoscopically Screenable Cancers in the United States.
Gastro Hep Adv
January 2024
GI Section, VA San Diego Healthcare System, San Diego, California.
Background And Aims: Gastrointestinal cancer incidence varies by race and ethnicity. In the United States (US), there are screening guidelines for esophageal cancer (EC) and colorectal cancer (CRC), but not gastric cancer (GC). We compared GC, CRC, and EC incidence among the most populous racial and ethnic groups to inform US interception strategies.
View Article and Find Full Text PDFGastroprotective Effect of Isoferulic Acid Derived from Foxtail Millet Bran against Ethanol-Induced Gastric Mucosal Injury by Enhancing GALNT2 Enzyme Activity.
Nutrients
July 2024
Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Excessive alcohol consumption has led to the prevalence of gastrointestinal ailments. Alleviating gastric disorders attributed to alcohol-induced thinning of the mucus layer has centered on enhancing mucin secretion as a pivotal approach. In this study, foxtail millet bran polyphenol BPIS was divided into two components with MW < 200 D and MW > 200 D by molecular interception technology.
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