AI Article Synopsis
- FAM72 is a protein-coding gene family on chromosome 1 in humans, consisting of four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D.
- Their relationship with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) raises interest, but the exact functions of FAM72 in neural stem cells are not fully understood.
- This review discusses the characteristics of FAM72, focusing on its expression patterns and its potential roles in cell cycle regulation, stem cell renewal, and its implications in neurogenesis and tumorigenesis.
Article Abstract
Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuint.2024.105853 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genome-wide identification of UDP-glycosyltransferases involved in flavonol glycosylation induced by UV-B irradiation in Eriobotrya japonica.
Plant Physiol Biochem
January 2025
College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China; Zhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Flavonol glycosides are secondary metabolites important for plant development and stress defense such as UV-B irradiation. UDP-glycosyltransferase (UGT) catalyzes the last step in the biosynthesis of flavonol glycosides. Eriobotrya japonica is abundant in flavonol glycosides, but UGTs responsible for accumulation of flavonol glycosides remain unknown.
View Article and Find Full Text PDFIdentification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.
PLoS Pathog
January 2025
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. The increased availability of parasite genome sequence data has revolutionised the study of PfEMP1 diversity across multiple P. falciparum isolates.
View Article and Find Full Text PDFIdentification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana.
PLoS Genet
January 2025
Université Paris-Saclay, INRAE, AgroParisTech, Institute Jean-Pierre Bourgin for Plant Sciences (IJPB), Versailles, France.
Gamete killers are genetic loci that distort segregation in the progeny of hybrids because the killer allele promotes the elimination of the gametes that carry the sensitive allele. They are widely distributed in eukaryotes and are important for understanding genome evolution and speciation. We had previously identified a pollen killer in hybrids between two distant natural accessions of Arabidopsis thaliana.
View Article and Find Full Text PDFTBX3 is Essential for Zygotic Genome Activation and Embryonic Development in Pigs.
Microsc Microanal
January 2025
Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
The pluripotency-related T-box family transcription factor TBX3 maintains mESC self-renewal and plays a key role in the development of several tissues, including the heart, mammary glands, limbs, and lungs. However, the role of TBX3 during porcine preimplantation embryo development remains unclear. In our research, TBX3 was knocked down by injecting dsRNA to explore the function of TBX3.
View Article and Find Full Text PDFMedicaid and the Promise for Cure.
JAMA Pediatr
January 2025
Department of Medicine, University of Florida, Gainesville.
Importance: Cell and gene therapies are revolutionizing the treatment landscape for children and adults with rare diseases and can be life-changing for patients and their families. Successful implementation of these new therapies into clinical practice depends on their accessibility and affordability, particularly through publicly funded Medicaid agencies, which cover many children and adults with rare diseases.
Objective: To provide a framework to broadly assess cell and gene therapies, evaluate payment options, and ensure equitable access through the lens of publicly funded Medicaid programs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!